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Molecular Biology videos

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A ki'ds explanation to what is DNA

What is DNA and what is it made of?

In this video, Dr Marta Gabryelska and her son Eryk talk about DNA, what it is made of, how cells make more DNA, and how DNA can be destroyed. They will also eat some skittles. Why skittles? You need to watch the video to find out!

Detailed microscope images of mitochondria and a photo of Dr Chloe Goldsmith while describing it.

Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level

Mammalian cytosine DNA methylation (5mC) is associated with the integrity of the genome and the transcriptional status of nuclear DNA. Due to technical limitations, it has been less clear if mitochondrial DNA is methylated and whether 5mC has a regulatory role in this context. Here, we used bisulfite-independent single-molecule sequencing of native human and mouse DNA to study mitochondrial 5mC across different biological conditions.

Illustration of various scientists wearing labcoats, measuring, climbing enormous RNA structure, looking through a magnifying glass and taking notes.

Predicting ZIKA virus RNA structure based on novel RNA-RNA interactomic data

The structural flexibility of RNA underlies fundamental biological processes, but there were no methods to explore the multiple conformations adopted by RNAs in vivo. We developed cross-linking of matched RNAs and deep sequencing (COMRADES) for in-depth RNA conformation capture, and a pipeline for the retrieval of RNA structural ensembles.

Using COMRADES, we determined the architecture of the Zika virus RNA genome inside cells and identified multiple site-specific interactions with human noncoding RNAs.

A big out-of-proportion chemical compound falling into a cell and causing a big splash. Few Zika virions surrounding it.

ZIKA virus genome structure based on RNA-RNA interactions

The zika virus genome is a single-stranded RNA molecule. Not much was known about its structure. A collaborative initiative between two Universities in the United Kingdom solved this riddle and developed a method to explore multiple conformations adopted by RNAs in vivo in virus-infected cells. Just like a person can fold their body into multiple yoga positions, the Zika virus genome can do similar. Watch this video to learn how!

The Zika virus and its comparison with a kinder surprise egg

The insides of the Zika virus

What has a virus in common with a kinder surprise egg? Surprisingly, a lot! Watch this video to learn how scientists can look into viruses and study their insides. In this video, you will learn about virions, capsids, and genomes. You might also get hungry!